Pathogens secrete a variety of macromolecules to survive within their host which manipulate the immunological response of the host in order to facilitate survival and proliferation of the pathogen. My work focuses primarily on the genus Mycobacterium, specifically M. tuberculosis, the causative agent of Tuberculosis. The main objective of this research is to understand the complex immunological host–pathogen interactions and the course of Tuberculosis by (1) elucidating the biochemical mechanisms by which Mtb proteins are involved in host signal transduction pathways, and (2) elucidating the means by which this interaction contributes to the survival and the establishment of a successful infection within the host. It is expected that the information obtained from these studies will suggest new therapeutic approaches and new targets to control bacterial infections.
Relevant NGDI Articles
Anti-biofilm activity of silver nanoparticles against different microorganisms. Martinez-Gutierrez F, Boegli L, Agostinho A, Sánchez EM, Bach H, Ruiz F, James G. Biofouling. 2013;29(6):651-60.
Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles. Martínez-Gutiérrez F, Guajardo-Pacheco JM, Noriega-Trevino ME, Thi EP, Reiner N, Orrantia E, Av-Gay Y, Ruiz F, Bach H. Future Microbiol. 2013 Mar;8(3):403-11.
Antimicrobial, antiparasitic, anti-inflammatory, and cytotoxic activities of Lopezia racemosa. Cruz Paredes C, Bolívar Balbás P, Gómez-Velasco A, Juárez ZN, Sánchez Arreola E, Hernández LR, Bach H. ScientificWorldJournal. 2013 Jun 12;2013:237438.
Chemical constituents, anti-inflammatory and antioxidant activities of bark extracts from Prunus tucumanensis Lillo. Bach SM, Perotti ME, Merep AP, Marcial GE, Grau A, Attarian R, Av-Gay Y, Bach H, Catalán CA. Nat Prod Res. 2013;27(10):916-9.
Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis. Gómez-Velasco A, Bach H, Rana AK, Cox LR, Bhatt A, Besra GS, Av-Gay Y. Microbiology. 2013 Apr;159(Pt 4):726-36.
Effect of inflammatory bowel disease therapies on immunogenicity of Mycobacterium paratuberculosis proteins. Xia A, Stempak JM, Grist J, Bressler B, Silverberg MS, Bach H. Scand J Gastroenterol. 2014 Feb;49(2):157-63.
Exploring the biological activities of Echeveria leucotricha. Martínez Ruiz MG, Gómez-Velasco A, Juárez ZN, Hernández LR, Bach H. Nat Prod Res. 2013;27(12):1123-6.
A closer look at the biosynthetic pathway of ergothioneine in Mycobacterium tuberculosis. Richard-Greenblatt M, Bach H and Av-Gay Y. FEBS J 2012 279:192.
Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Laennecia confusa. Martinez Ruiz MG, Richard-Greenblatt M, Juarez ZN, Av-Gay Y, Bach H and Hernandez LR. Scientific World J 2012:263572.