Research in the Hafeli Laboratory is primarily directed at fighting cancer with radioactive pharmaceuticals and the development of diagnostic radiopharmaceuticals to be used in different Nuclear Medicine procedures. He also enjoys exploiting nanotechnology and microtechnology for different drug delivery applications, including the development of painless microneedles and the use of microfluidics for the preparation of monosized microspheres. The Hafeli laboratory is also investigating new ways of preparing uniform magnetic and non-magnetic microspheres, made from biodegradable materials and appropriate for intravascular human use.
Relevant NGDI Articles
Continuously manufactured magnetic polymersomes–a versatile tool (not only) for targeted cancer therapy. Bleul R, Thiermann R, Marten GU, House MJ, St Pierre TG, Häfeli UO, Maskos M. Nanoscale. 2013 Dec 7;5(23):11385-93.
Uniform polymer microspheres: monodispersity criteria, methods of formation and applications. De La Vega JC, Elischer P, Schneider T, Häfeli UO. Nanomedicine (Lond). 2013 Feb;8(2):265-85. Review.
Effects of chemical and physical parameters in the generation of microspheres by hydrodynamic flow focusing. Schneider T, Chapman GH, and Häfeli UO. Colloids and Surfaces 2011, Vol87:2:361-368.
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles. Laurent S, Dutz S, Häfeli UO, and Mahmoudi M. Advances in Colloid and Interface Science 2011, Vol166:1-2:8-23.