Project Names: Ferrocenyl-carbohydrate Conjugates in Malaria listed on the Drug Discovery page.
Research projects in our labs study the roles of metal ions in the etiology, diagnosis, and therapy of disease. These projects encompass a variety of metal ions as well as numerous ligand systems and a wide panoply of techniques and collaborations. Synthesis of organic ligands and inorganic complexes as well as physical (potentiometric and spectrophotometric titrations, various spectroscopies, electrochemistry etc.) and biological studies (in cells, at UBC Bioservices and/or in collaboration) are undertaken in the research programme. There is a need for different categories of anti-malarials, active against the resistant strains. An attractive area of research for new malarial treatment is directed metal conjugates, particularly those of known anti-malarial drugs.
Relevant NGDI Articles
H(4)octapa-trastuzumab: versatile acyclic chelate system for 111In and 177Lu imaging and therapy. Price EW, Zeglis BM, Cawthray JF, Ramogida CF, Ramos N, Lewis JS, Adam MJ, Orvig C. J Am Chem Soc. 2013 Aug 28;135(34):12707-21.
Matching chelators to radiometals for radiopharmaceuticals. Price EW, Orvig C. Chem Soc Rev. 2014 Jan 7;43(1):260-90.
Metalloantimalarials. Salas PF, Herrmann C, Orvig C. Chem Rev. 2013 May 8;113(5):3450-92. Review.
Structural characteristics of chloroquine-bridged ferrocenophane analogues of ferroquine may obviate malaria drug-resistance mechanisms. Salas PF, Herrmann C, Cawthray JF, Nimphius C, Kenkel A, Chen J, de Kock C, Smith PJ, Patrick BO, Adam MJ, Orvig C. J Med Chem. 2013 Feb 28;56(4):1596-613.
1,2-Disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents. Herrmann C, Salas PF, Patrick BO, De Kock C, Smith PJ, Adam MJ and Orvig C. Dalton Trans 2012 41(21):6431-6442.