UBC C. elegans Gene Knockout Laboratory:
The UBC C. elegans Gene Knockout Laboratory is part of an international consortium, working to produce null mutations in identified and predicted genes in the C. elegans (pictured below) genome. Our gene targets include those with human homologs, many of which may be implicated in human genetic disease, as well as a set that are nematode specific. These latter genes are important from a human health perspective and because nematodes are major agricultural pests. Determining the function of genes specific to nematodes could offer the pharmaceutical industry new target proteins for nematicide development.
Relevant NGDI Articles
A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans. Gysi S, Rhiner C, Flibotte S, Moerman DG, Hengartner MO. PLoS One. 2013 Sep 16;8(9):e74908. eCollection 2013.
Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis. Labrador L, Barroso C, Lightfoot J, Müller-Reichert T, Flibotte S, Taylor J, Moerman DG, Villeneuve AM, Martinez-Perez E. PLoS Genet. 2013 May;9(5):e1003497.
CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans. Warner A, Xiong G, Qadota H, Rogalski T, Vogl AW, Moerman DG, Benian GM. Mol Biol Cell. 2013 Mar;24(5):601-16.
The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation. Steimel A, Suh J, Hussainkhel A, Deheshi S, Grants JM, Zapf R, Moerman DG, Taubert S, Hutter H. Dev Biol. 2013 May 15;377(2):385-98.
The million mutation project: a new approach to genetics in Caenorhabditis elegans. Thompson O, Edgley M, Strasbourger P, Flibotte S, Ewing B, Adair R, Au V, Chaudhry I, Fernando L, Hutter H, Kieffer A, Lau J, Lee N, Miller A, Raymant G, Shen B, Shendure J, Taylor J, Turner EH, Hillier LW, Moerman DG, Waterston RH. Genome Res. 2013 Oct;23(10):1749-62.
Unexpected role for dosage compensation in the control of dauer arrest, insulin-like signaling, and FoxO transcription factor activity in Caenorhabditis elegans. Dumas KJ, Delaney CE, Flibotte S, Moerman DG, Csankovszki G, Hu PJ. Genetics. 2013 Jul;194(3):619-29.