Professor
Chemistry |Faculty of Science
Professor | Biochemistry & Molecular Biology | Faculty of Medicine
Phone:
6048223341
Website:
Research Interests:

The goal of the ASTRID group is to use the tools of X-ray crystallography and NMR spectroscopy to determine the three-dimensional structures of proteins critical to infectious diseases. This information provides a “molecular blueprint” for understanding infectious diseases and for developing therapies. Particular emphasis is placed on the “super bugs” that increasingly threaten global health.

Relevant NGDI Articles

2013

¹H, ¹³C and ¹⁵N resonance assignments and peptide   binding site chemical shift perturbation mapping for the Escherichia coli redox enzyme chaperone DmsD. Stevens CM, Okon M, McIntosh LP, Paetzel M. Biomol NMR Assign. 2013 Oct;7(2):193-7.

Detection and characterization of serine and threonine hydroxyl    protons in Bacillus circulans xylanase by NMR spectroscopy.  Brockerman JA, Okon M, McIntosh LP. J Biomol NMR. 2014 Jan;58(1):17-25.

Investigating the structural dynamics of α-1,4-galactosyltransferase C from Neisseria meningitidis by nuclear magnetic resonance spectroscopy. Chan PH, Cheung AH, Okon M, Chen HM, Withers SG, McIntosh LP. Biochemistry. 2013 Jan 15;52(2):320-32.

Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation. Cetinbas N, Huang-Hobbs H, Tognon C, Leprivier G, An J, McKinney S, Bowden M, Chow C, Gleave M, McIntosh LP, Sorensen PH. J Biol Chem. 2013 Sep 27;288(39):27940-50.

Protein dielectric constants determined from NMR chemical shift perturbations. Kukic P, Farrell D, McIntosh LP, García-Moreno E B, Jensen KS, Toleikis Z, Teilum K, Nielsen JE. J Am Chem Soc. 2013 Nov 13;135(45):16968-76.

Steric Mechanism of Auto-Inhibitory Regulation of   Specific and Non-Specific DNA Binding by the ETS  Transcriptional Repressor ETV6. De S, Chan AC, Coyne HJ 3rd,  Bhachech N, Hermsdorf U, Okon M, Murphy ME, Graves BJ, McIntosh LP. J Mol Biol. 2013 Dec 12. pii: S0022-2836(13)00747-X.

Strategies for modulating the pH-dependent activity of a family 11 glycoside hydrolase. Ludwiczek ML, D’Angelo I, Yalloway GN, Brockerman JA, Okon M, Nielsen JE, Strynadka NC, Withers SG, McIntosh LP. Biochemistry. 2013 May 7;52(18):3138-56.

Structure-function analysis of a broad specificity Populus trichocarpa endo-β-glucanase reveals an evolutionary link  between bacterial  licheninases and plant XTH gene products. Eklöf JM, Shojania S, Okon M, McIntosh LP, Brumer H. J Biol Chem. 2013 May 31;288(22):15786-99.

2012

A protein export pathway involving Escherichia coli porins. Prehna G, Zhang G, Gong X, Duszyk M, Okon M, McIntosh LP, Weiner JH and Strynadka NCJ.  Structure 2012 20(7):1154-1166.

Nuclear magnetic resonance spectral assignments of alpha-1,4- galactosyltransferase lgtc from neisseria meningitidis: Substrate binding and multiple conformational states. Chan PHW, Weissbach S, Okon M, Withers SG and McIntosh LP. Biochemistry 2012 51(41):8278-8292.

The zinc regulated antivirulence pathway of Salmonella is a multiprotein immunoglobulin adhesion system. Prehna G, Li Y, Stoynov N, Okon M, Vuckovic M, McIntosh LP, Foster LJ, Finlay BB and Strynadka NCJ. J Biol Chem 2012 287(39):32324-32337.