Our laboratory is developing a vaccine system that with only one immunization given at birth will protect from infectious diseases, as well as from asthma and allergies. Our laboratory uses state-of-the-art lab technology and bioinformatic approaches to get the most information out of the smallest samples. We are systematically dissecting the molecular mechanisms important in the human neonatal and infant response to infection or vaccination important for global health. Based on that knowledge, we are identifying immune modulators or vaccine adjuvants that help protect newborns from disease, and aid in their immune response to vaccines. This work is done in close collaboration with several large national and international research groups.
Relevant NGDI Articles
Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes. Sherrid AM, Kollmann TR. Clin Dev Immunol. 2013;2013:917198. Review.
Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life. Reikie BA, Naidoo S, Ruck CE, Slogrove AL, de Beer C, la Grange H, Adams RC, Ho K, Smolen K, Speert DP, Cotton MF, Preiser W, Esser M, Kollmann TR. Clin Vaccine Immunol. 2013 Jan;20(1):33-8.
Assessment of HPV 16 and HPV 18 antibody responses by pseudovirus neutralization, Merck cLIA and Merck total IgG LIA immunoassays in a reduced dosage quadrivalent HPV vaccine trial. Krajden M, Cook D, Yu A, Chow R, Su Q, Mei W, McNeil S, Money D, Dionne M, Palefsky J, Karunakaran K, Kollmann T, Ogilvie G, Petric M, Dobson S. Vaccine. 2013 Sep 19. pii: S0264-410X(13)01234-6.
Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates. Cho P, Gelinas L, Corbett NP, Tebbutt SJ, Turvey SE, Fortuno ES 3rd, Kollmann TR. Genes Immun. 2013 Jun;14(4):199-211.
Clostridium difficile vertebral osteomyelitis. Al-Najjar A, Al-Rawahi GN, Hoang LM, Kollmann TR. Pediatr Infect Dis J. 2013 Sep;32(9):1030-2.
Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study. Al-Dabbagh M, Lapphra K, Scheifele DW, Halperin SA, Langley JM, Cho P, Kollmann TR, Li Y, De Serres G, Fortuno ES 3rd, Bettinger JA. Clin Vaccine Immunol. 2013 Aug;20(8):1108-14.
Host defense against common early life-threatening infections. Bortolussi R, Henneke P, Kollmann T. Clin Dev Immunol. 2013;2013:350808.
Immune response to vaccine adjuvants during the first year of life. Levy O, Goriely S, Kollmann TR. Vaccine. 2013 May 17;31(21):2500-5.
Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial. Dobson SR, McNeil S, Dionne M, Dawar M, Ogilvie G, Krajden M, Sauvageau C, Scheifele DW, Kollmann TR, Halperin SA, Langley JM, Bettinger JA, Singer J, Money D, Miller D, Naus M, Marra F, Young E. JAMA. 2013 May 1;309(17):1793-802.
Pattern recognition receptor-mediated cytokine response in infants across 4 continents. Smolen KK, Ruck CE, Fortuno ES 3rd, Ho K, Dimitriu P, Mohn WW, Speert DP, Cooper PJ, Esser M, Goetghebuer T, Marchant A, Kollmann TR. J Allergy Clin Immunol. 2013 Nov 28. pii: S0091-6749(13)01487-5.
Vaccine-induced immunity in early life. Kollmann TR, Levy O, Hanekom W. Vaccine. 2013 May 17;31(21):2481-2.
Variation between Populations in the Innate Immune Response to Vaccine Adjuvants. Kollmann TR. Front Immunol. 2013 Apr 2;4:81. eCollection 2013.
HIV-exposed uninfected infants are at increased risk for severe infections in the first year of life. Slogrove A, Reikie B, Naidoo S, De Beer C, Ho K, Cotton M, Bettinger J, Speert D, Esser M and Kollmann T. J Trop Pediatr 2012 58(6):505-508.
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly. Kollmann TR, Levy O, Montgomery RR and Goriely S. Immunity 2012 37(5):771-783.
Management of multi-drug-resistant tuberculosis in children. Al-Dabbagh M, Driessche KV, Marais BJ and Kollmann TR. Eur Infect Dis 2012 6(1):35-40.
Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of South African Infants throughout the First Year of Life. Reikie BA, Adams RCM, Ruck CE, Ho K, Leligdowicz A, Pillay S, Naidoo S, Fortuno III ES, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M and Kollmann TR. PLoS ONE 2012 7(9)
Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria. Shey MS, Hughes EJ, De Kock M, Barnard C, Stone L, Kollmann TR, Hanekom WA and Scriba TJ. J Immunol Methods 2012 376(1-2):79-88.
Uninfected but not unaffected: Chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections. Dauby N, Goetghebuer T, Kollmann TR, Levy J and Marchant A. Lancet Infect Dis 2012 12(4):330-340.
Drug-resistant Tuberculosis. Al-Dabbagh M, Lapphra K, McGloin R, Inrig K, Schaaf HS, Marais BJ, Sauve L, Kitai I, and Kollmann TR. The Pediatric Infectious Disease Journal 2011, Vol30:6:501-505.
Drug-resistant Tuberculosis: Pediatric guidelines. l-Dabbagh M, Lapphra K, McGloin R, Inrig K, Schaaf HS, Marais BJ, Sauve L, Kitai I, and Kollmann TR. The Pediatric Infectious Disease Journal. 2011, Vol30:6:501-505.