Viruses cause a large number of diseases in man and our goal is to thoroughly understand how viruses become recognized by host lymphocytes. It is now clear that an initial event in host recognition of viruses is the breakdown of viral proteins into small subunits or peptides prior to the triggering of T lymphocytes. It is clear from our work that the different characteristics of different viruses greatly influence the efficiency and requirements for protein degradation, recruitment and presentation of vital peptides. We hope that by understanding the rules of antigen processing and presentation we will be in a position to modulate immune
responses against particular viruses and thereby limit viral pathogenesis in man.
Relevant NGDI Articles
Towards the conservation of endangered avian species: a recombinant West Nile Virus vaccine results in increased humoral and cellular immune responses in Japanese Quail (Coturnix japonica). Young JA, Jefferies W. PLoS One. 2013 Jun 25;8(6):e67137.
Weft, warp, and weave: the intricate tapestry of calcium channels regulating T lymphocyte function. Omilusik KD, Nohara LL, Stanwood S, Jefferies WA. Front Immunol. 2013 Jun 24;4:164. eCollection 2013.